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Attorney General Martha Coakley's Office Reaches $22 Million Medicaid Fraud Settelement From Eli Lilly
Massachusetts Attorney General Martha Coakley"s Office has reached an agreement with pharmaceutical manufacturer Eli Lilly & Co. ("Lilly"), resolving allegations that the company engaged in the improper marketing of its atypical antipsychotic drug, Zyprexa. Under the terms of the settlement, Lilly has paid $22,499,433.04 to the Massachusetts Medicaid Program, which provides funds for health care products and services to eligible low-income individuals, including people with disabilities, children and elder citizens.
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Editorial Discusses Removal Of Needle Exchange Funding Ban
A Wilmington News Journal editorial discussed the potential lifting of the ban on using federal funding for needle exchange programs. The editorial notes recent Congressional action and the restrictions in a House bill that prohibit needle exchanges to operate "within a 1,000 feet of day care centers, schools, parks, playgrounds, pools and youth centers." According to the News Journal, "This rule wipes out much of the flexibility many cities need in their fight to prevent the spread of HIV among intravenous drug users. The nation"s capital, where the rates of HIV and AIDS cases are considered epidemic, would be hit the hardest because no part of the District of Columbia would be eligible for the funding according to AIDS Action." The editorial adds, "Vans patrolling near vulnerable populations - specifically young, impressionable children - are an issue that must be addressed. But well-intentioned limits should not be allowed to hold up the rest of the program," according to the News Journal (8/1).
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H1N1 Spread Continues Worldwide; First Death In Asia Confirmed
The H1N1 (swine flu) virus has now infected more than 52,000 people, leaving 231 dead, the WHO said Monday, AFP/Washington Post reports. "Swine flu has now been reported in 100 countries and territories, and figures yet to be incorporated into the U.N. health agency"s official figures indicate an even higher toll," AFP/Washington Post writes, adding, "The WHO said, however, that its figures could not be considered reliable because some countries were no longer keeping total figures while other poor countries did not have the means to reliably detect cases." Since Friday, the number of cases has grown by more than 7,873 cases and 51 deaths, "highlighting the steady spread of the virus," the newspaper writes (AFP/Washington Post, 6/23).
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Predicting Higher Risk For Prostate Cancer Diagnosis

High-grade prostatic intraepithelial neoplasia (HGPIN) carries a high predictive value for future diagnosis of prostate cancer. Research published in the open access journal BMC Urology has shown that 41.8% of patients whose extended core biopsy led to an initial diagnosis of HGPIN were subsequently diagnosed with prostate cancer. Paras Singh and Francis Martin, from Lancashire Teaching Hospitals NHS Foundation Trust and Lancaster University, along with their co-workers, conducted a retrospective analysis of the institution"s pathology database, investigating the occurrence of prostate cancer in patients initially diagnosed with HGPIN. They also calculated the risk of developing prostate cancer based on initial levels of PSA. They said, "Of 2,192 biopsied patients, there were 88 cases of isolated HGPIN of which 67 patients underwent one or more repeat biopsies. In this repeat-biopsy group, 28 prostate cancer diagnoses were made. Age at first biopsy, higher baseline PSA and higher change in PSA were all predictive of cancer detection on repeat biopsies". There has been speculation that an initial diagnosis of HGPIN may not be a useful indicator of the future risk of prostate cancer. The authors acknowledge that the 41.8% risk they identified is higher than that found by most contemporary studies, but point out that it is comparable to an earlier US-based study from when there was lower level of PSA screening, perhaps similar to the current situation in the UK. The researchers conclude, "HGPIN carries a high predictive value for future diagnosis of prostate cancer. Based on our results, we recommend delaying the first repeat biopsy at low PSA range but to have a shorter interval to repeat biopsies at intermediate and higher PSA ranges". Risk of prostate cancer after detection of isolated high-grade prostatic intraepithelial neoplasia (HGPIN) on extended core needle biopsy: a UK hospital experience Paras B Singh, Caroline M Nicholson, Narasimhan Ragavan, Rosemary A Blades, Francis L Martin and Shyam S Matanhelia BMC Urology (in press) http://www.biomedcentral.com/bmcurol/ Graeme Baldwin BioMed Central


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