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Gene Test Determines Transplant Drug Tolerance
A simple genetic test can determine a kidney transplant patient"s tolerance for a potent anti-rejection medication, according to an upcoming study in the Journal of the American Society Nephrology (JASN). The test could allow doctors to individualize each patient"s dose, optimizing the drug"s benefits and minimizing its side effects.
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Watson Pharmaceuticals Receives A Complete Response Letter For Its 24-Week Formulation Of TRELSTAR(R) (triptorelin Pamoate) NDA From US FDA
Watson Pharmaceuticals, Inc. (NYSE: WPI), a leading specialty pharmaceutical company, announced that it received a Complete Response Letter from the U.S. Food and Drug Administration (FDA) on its New Drug Application (NDA) for TRELSTAR(R) 22.5 mg (triptorelin pamoate for injectable suspension), a 24-week formulation of TRELSTAR(R) for the palliative treatment of advanced prostate cancer. The TRELSTAR(R) NDA was prepared in cooperation with Debiopharm Group, a Swiss-based global biopharmaceutical group of companies.
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Obama Announces Appeals Court Judge Sotomayor As Supreme Court Nominee
President Obama this morning announced Judge Sonia Sotomayor of the Second Circuit Court of Appeals as his nominee to replace retiring Supreme Court Justice David Souter, the New York Times" "The Caucus" reports. Sotomayor, if confirmed, would be the first Hispanic to serve on the court and, with Justice Ruth Bader Ginsburg, bring the number of female justices currently on the court to two. White House officials said the president made his decision over the Memorial Day weekend after narrowing his list of candidates to four. s close to the selection process said the other candidates included Federal Appeals Judge Diane Wood, Homeland Security Secretary Janet Napolitano and Solicitor General Elena Kagan (Zeleny, "The Caucus," New York Times, 5/26). According to the Washington Post, Obama has set a deadline of having Sotomayor confirmed before the Senate"s five-week recess that begins Aug. 7 (Shear et al., Washington Post, 5/26). Sotomayor, a graduate of Princeton University and Yale Law School, joined the federal district court in 1992 after being nominated by former President George H.W. Bush. Former President Clinton nominated her to the appeals court in 1997, and she was confirmed in 1998 (Baker/Zeleny, New York Times, 5/26). The Post reports that many analysts considered Sotomayor a likely pick to replace Souter, who announced his retirement earlier this month (Washington Post, 5/26). According to the Times, Sotomayor"s past statements that her ethnicity and gender are important factors in serving as a judge "could generate debate" during the nomination process. In a 2002 lecture, Sotomayor said, "I would hope that a wise Latina woman with the richness of her experiences would more often than not reach a better conclusion than a white male who hasn"t lived that life" (New York Times, 5/26). Both liberal and conservative advocates were quick to release statements on the selection after the announcement this morning. Doug Kendall, president of the liberal Constitution Accountability Center, said, "We already know that she is a brilliant lawyer who is committed to ruling based on the Constitution and the law, not on her own personal political views." Wendy Long, counsel to the conservative Judicial Confirmation Network, said in an e-mail to reporters that Sotomayor "is a liberal judicial activist of the first order who thinks her own personal political agenda is more important than the law as written. She thinks that judges should dictate policy, and that one"s sex, race and ethnicity ought to affect the decisions one renders from the bench" (Washington Post, 5/26). According to Politico, of the nominees Obama was considering, Sotomayor was the one that Republicans indicated "they would complain most loudly about." However, the Democratic control of the Senate makes it unlikely that Republicans could block her confirmation, Politico reports (Allen/Martin, Politico, 5/26). Over the weekend, Senate Minority Whip Jon Kyl (R-Ariz.), a member of the Senate Judiciary Committee, said that senators from both parties "reserve the right to not only oppose a nomination, but also prevent the vote on a nomination" (Wilson, The Hill, 5/25). Kyl also said that although the GOP likely does not have enough votes for a filibuster, he would attempt to delay the nomination if Obama chose someone outside what he considers the mainstream. He said, "We will distinguish between a liberal judge on one side and one who doesn"t decide cases on the merits but, rather, on the basis of his or her preconceived ideas" (Washington Times, 5/25). Obama Discusses Nomination in C-SPAN InterviewIn an interview on Friday with C-SPAN, Obama said he would like to choose a Supreme Court justice who has "a little bit of a common touch" and a "practical sense of how the world works," the Post reports. Obama added that he "continue[s] to believe" that "empathy" is an important quality in a justice, despite Republican criticism that his emphasis on the quality means that he seeks a judge with an "activist" agenda, the Post reports
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New Training And Education Programme Introduced For The Scientific Workforce In Genetics, UK

A new education programme has been developed to provide enhanced training in genetic technologies and clinical applications for healthcare scientists working in laboratory genetics, Health Minister Ann Keen announced. This pilot is part of the UK Modernising Scientific Careers (MSC) programme which is transforming education, training and career pathways for the healthcare science workforce. The pilot funded by the Department of Health is investing over ÷£4.5 million to address the training needs of the healthcare science workforce in genetics. The new pilot will: - Respond to future workforce needs, which has increased significantly in the last ten years as scientific discoveries have created new opportunities to diagnose and predict disease; - Inform the roll out of the MSC programme for other healthcare science training programmes which will begin in 2010 with full implementation in 2012; - Establish a national School of Genetics in the West Midlands; and - Modernise the genetics curricula to respond to breakthrough scientific advances and their applications for patients and the public. Health Minister Ann Keen said: "Science and innovation are at the heart of high quality healthcare for patients in the 21st century, underpinning the development of new diagnostics and treatments which have a major impact on the health and social care system. "Geneticists carry out life informing work by predicting and diagnosing disease so it is fundamental that we invest in creating training and career opportunities for this important group of NHS staff". "This pilot will also inform the Modernising Scientific Careers programme as it moves to implementation as well as creating a high quality healthcare science workforce which will make the benefits of science and technology a reality for patients." Professor Sue Hill, Chief Scientific Officer for the Department of Health said: "This will give trainees modernised education and training focussed on the advances in genetic technology and knowledge to ensure delivery of leading edge services for patients and the public. It also supports the delivery of the NHS Next Stage Review commitments putting high quality care, innovation and improved productivity at its core in this fast-moving field. "I look forward to working with those involved in the pilot and to consulting with MSC stakeholders as it progresses." Peter Blythin, Director of Nursing and Workforce at NHS West Midlands said: "We are delighted to be hosting and establishing a national School of Genetics here in the West Midlands and to be part of such a groundbreaking pilot scheme that will ultimately deliver leading edge services for patients and the public." The pilot programme, to begin in October 2009, will fund 24 pilot training posts for 12 trainee Healthcare Science Practitioners and 12 Healthcare Scientists in Genetics. The trainees will be based in a number of NHS genetics departments throughout England and will be brought together for national training events and courses. NHS West Midlands has agreed to host the process for all the SHAs involved. Department of Health, UK


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