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ACOG Refines Fetal Heart Rate Monitoring Guidelines
Refinements of the definitions, classifications, and interpretations of fetal heart rate (FHR) monitoring methods were issued today in new guidelines released by The American College of Obstetricians and Gynecologists (ACOG). The objective of the guidelines is to reduce the inconsistent use of common terminology and the wide variability that sometimes occurs in FHR interpretations. ACOG"s Practice Bulletin, published in the July 2009 issue of Obstetrics & Gynecology, supports the recommendations of the Eunice Kennedy Shriver National Institute of Child and Health Development workshop* on electronic fetal monitoring (EFM) held in April 2008.
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Jaloma Pacifiers Recalled Due To Choking Hazard
The Connecticut Department of Consumer Protection is notifying consumers about a voluntary recall announced by the U.S. Consumer Product Safety Commission. The recalled Jaloma Pacifiers were sold in retail stores in New Jersey and New York from February 2008 through March 2009, for approximately $1.00. Although not sold in Connecticut stores, this recalled product may have been purchased while visiting the above noted states or may have been sent to Connecticut as a gift. The pacifiers were manufactured in Mexico and imported by Gromex Inc., of Passaic, New Jersey. Although no injuries and/or incidents have been reported, the potential for injury is high due to the pacifier mouth guard and the ventilation holes are too small and fail to meet federal safety standards, for this reason, the pacifier poses a choking hazard to young children.
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HIMSS Electronic Health Record Association Supports Achievable 'Meaningful Use' Criteria In Comments To ONC
The Electronic Health Records Association (EHR Association) has made specific recommendations to the Office of the National Coordinator for Health Information Technology (ONC) on measurable criteria for achieving "meaningful use" of electronic health records (EHRs), as called for in the American Recovery and Reinvestment Act of 2009 (ARRA). The Association specifically calls for 2011 objectives to be based on software and standards that are currently deployed and implemented, with a focus on adoption and use of comprehensive EHRs and recognition of the need for differences between inpatient and ambulatory meaningful use criteria.
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New Location Found For Regulation Of RNA Fate

Thousands of scientists and hundreds of software programmers studying the process by which RNA inside cells normally degrades may soon broaden their focus significantly. That"s because University of Wisconsin-Madison researchers have discovered that the RNA degradation, which, when improperly regulated can lead to cancer and other diseases, can be launched in an unexpected location. "We"ve been seeing only half the picture," says Vladimir Spiegelman, lead author on the new study and associate professor of dermatology at the UW-Madison School of Medicine and Public Health. The Wisconsin team also found that CRD-BP, a protein activated in colorectal and other cancers, can prevent RNA from degrading in the newly identified spot. The finding may have broad implications for cancer research as well as biology in general. "The finding is important for the proto-oncogenes, or precursor cancer genes, we study, but it may be even more important for the thousands of other genes and proteins that are regulated in a similar way," says Spiegelman. The study appears in the July 31 issue of Molecular Cell. Spiegelman and his team study proto-oncogenes and other potential "cancer-causers" normally found in cells, analyzing them as they are "converted" from DNA into RNA and ultimately active proteins that can lead to cancer. It"s the same multistep process all genes in a cell - including "cancer-preventers" such as tumor suppressors, anti-inflammatory factors and cell death promoters - go through. Controls at each step usually keep the process working smoothly, but if a control fails at any number of places along the way, a cancer-promoting gene can tilt the delicately balanced scale toward malignancy. In their previous work, the Wisconsin researchers found that regulation of some proto-oncogenes occurs after CRD-BP binds to messenger RNA (mRNA). During this intermediary step, mRNA is typically either degraded or goes on unharmed to the next step of translation. The Wisconsin team showed that the mRNA bound by CRD-BP was not degraded, and thus became an active protein - in this case, a full-fledged cancer-causing oncogene. Until the Spiegelman group"s latest study appeared, scientists assumed that the regulation of mRNA fate took place exclusively in an area of the RNA strand called the 3 prime untranslated region, where small regulatory RNAs called microRNAs (miRNA) bind and inhibit mRNAs. But the Wisconsin team found degradation can also be initiated in an area on the mRNA strand called the coding region. "This changes the paradigm," says Spiegelman. "Now we can examine this important activity in two places." The researchers demonstrated that degradation occurs here using a human mRNA, and described the mechanism by which CRD-BP stabilizes the mRNA and prevents it from degrading and expressing more protein. "This may be the first example of a negative regulator of an miRNA-dependent RNA-degrading mechanism," Spiegelman says. The mechanism is relevant to many proteins, he says. "Understanding this mechanism should also help us in studying cell signaling pathways related to pro-inflammatory and cell death factors that contribute to tumor development," he says. Dian Land University of Wisconsin-Madison


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