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Older People Benefit From Progressive Resistance Strength Training
Progressive resistance strength training not only helps older adults become stronger but also makes their everyday life easier, a Cochrane Review suggests.
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Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, And BRAF Gene Mutations In Reflex Testing Service
Quest Diagnostics Incorporated (NYSE: DGX), the world"s leading cancer diagnostics company, today launched the EGFR Pathway test (KRAS with reflex to NRAS, BRAF), the first laboratory-developed test from a national commercial reference laboratory for comprehensively identifying, in a single reflex test offering, genetic mutations in the KRAS, NRAS and BRAFL genes. The test is designed to aid the identification of the roughly half of all metastatic colorectal cancer (mCRC) patients who, because of certain mutations of the epidermal growth factor receptor (EGFR) pathway, are believed to be unresponsive to anti-EGFR cancer therapies for mCRC. While some commercial laboratory tests for predicting anti-EGFR response analyze certain mutations of the KRAS and BRAF genes, such as codons 12 and 13 of KRAS, the Quest Diagnostics test detects mutations in codons 12, 13 and 61 of both the KRAS and NRAS genes and mutations in exons 11, 12, and 15 of the BRAF gene, in a sequential reflex manner.
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Study Demonstrated Once-Daily Vyvanse(R) CII Provided Significant Improvement Of ADHD Symptoms For Children At 13 Hours After Administration
Shire plc announced that a study published online in the peer-reviewed journal Child and Adolescent Psychiatry and Mental Health found once-daily Vyvanse® (lisdexamfetamine dimesylate) CII significantly reduced the symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) in children aged 6 to 12 from the first time point measured (1.5 hours) up to the last time point assessed (13 hours) after administration. In this pediatric analog classroom study, treatment with Vyvanse was associated with significant improvement in behavior and attention in children at each time point measured, with improvement at 13 hours after administration.
Diagnostics

Lung Cancer Risk May Be Increased By Ovary Removal

Women who have premature menopause because of medical interventions are at an increased risk of developing lung cancer, according to a new study published in the International Journal of Cancer. The startling link was made by epidemiologists from the Universitçİ de Montrçİal, the Research Centre of the Centre Hospitalier de l"Universitçİ de Montrçİal and the INRS - Institut Armand-Frappier. "We found that women who experienced non-natural menopause are at almost twice the risk of developing lung cancer compared to women who experienced natural menopause," says Anita Koushik, a researcher at the Universitçİ de Montrçİal"s Department of Social and Preventive Medicine and a scientist at the Research Centre of the Centre Hospitalier de l"Universitçİ de Montrçİal. "This increased risk of lung cancer was particularly observed among women who had non-natural menopause by having had both their ovaries surgically removed." The scientists studied 422 women with lung cancer and 577 control subjects at 18 hospitals across Montreal, Quebec, Canada. They assessed socio-demographic characteristics, residential history, occupational exposures, medical and smoking history, and (among women) menstruation and pregnancy histories. "A major strength of this study was the detailed smoking information which we obtained from all study participants; this is important because of the role of smoking in lung cancer and because smokers generally have lower estrogen levels than non-smokers," says Dr. Koushik. "Although smoking is the dominant cause of lung cancer, we know other factors can play an important role in enhancing the impact of tobacco carcinogens; this research suggests that in women hormonal factors may play such a role." Women were considered menopausal if their menstrual periods had stopped naturally, surgically (by hysterectomy with bilateral surgical ovary removal) or because of radiation or chemotherapy. Women who had at least one remaining ovary and who still had their menstrual periods at the time of diagnosis/interview were classified as premenopausal. Among participants with natural menopause, the median age for attaining menopause was 50 years old; among those with non-natural menopause, it was at 43 years. "Non-natural menopause, particularly surgical menopause, may represent an increased risk with younger age at menopause given that surgery is usually done before natural menopause occurs. It"s possible that vulnerability to lung cancer is caused by early and sudden decrease in estrogen levels or potentially long-term use of hormone replacement therapy and further research is needed to explore these hypotheses," says Jack Siemiatycki a professor at the Universitçİ de Montrçİal"s Department of Social and Preventive Medicine and a scientist at the Research Centre of the Centre Hospitalier de l"Universitçİ de Montrçİal. About the Study: The article "Characteristics of menstruation and pregnancy and the risk of lung cancer in women," published in the International Journal of Cancer, was authored by Anita Koushik and Jack Siemiatycki of the Universitçİ de Montrçİal and Research Centre of the Centre Hospitalier de l"Universitçİ de Montrçİal and Marie-Elise Parent of the INRS - Institut Armand-Frappier. Partners in Research: This study was funded by the Canadian Institutes of Health Research, the Fonds de la recherche en santçİ du Quçİbec and the Guzzo-SRC Chair in Environment and Cancer. Sylvain-Jacques Desjardins University of Montreal


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