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House Democrats To Unveil Health Care Bill Details
"After a series of false starts, House Democrats are finally expected to unveil the details of a sweeping reform measure on Tuesday that would drastically revamp the country"s health care system," Politico reports. "Party leaders had initially planned to introduce legislation last week and start considering it in committees this week. But that timeline was scuttled when a parade of moderates threw up their arms last week at a draft of the bill offered weeks earlier by the three chairmen writing it." While the Democrats "know that the clock is ticking-that the slower the process goes, the more time opponents will have to plant doubts in the minds of voters," Republicans are "feeling giddy-free to stand back and watch as Democrats fight amongst themselves."
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Trubion Announces Acceptance Of Three Presentations On Its TRU-016 Product Candidate At The 2009 ASCO Annual Meeting
Trubion Pharmaceuticals, Inc. (Nasdaq: TRBN) announced the acceptance of three data presentations on its proprietary product candidate, TRU-016, that will be given at the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting May 29 through June 2 in Orlando, Fla. The presentations will include positive data from a Phase 1 clinical trial of TRU-016 for the treatment of chronic lymphocytic leukemia (CLL), a preclinical study demonstrating the additive or synergistic effects of TRU-016 in combination with other therapeutic drugs for the treatment of non-Hodgkin"s lymphoma (NHL), and a preclinical study evaluating the effect of TRU-016 on direct apoptosis in CLL cells.
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Kaiser Permanente Survey Shows Seniors Embrace Internet To Manage Their Health
New data show that Medicare beneficiaries registered to use My Health Manager, Kaiser Permanente"s personal health record, are overwhelmingly satisfied with using the Internet to manage their health care online. Results from the recent Kaiser Permanente survey examining Web site usage and Medicare beneficiary satisfaction were presented today at the World Health Care Congress" 5th Annual Leadership Summit on Medicare in Washington, D.C.
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Good News And Bad For Dad This Father's Day - New Study Explores Dad's Role In Shaping A Healthy Baby

It was long believed that conception does not involve a meeting of equals. The egg is a relatively large, impressive biological factory compared with the tiny sperm, which delivers to the egg one copy of the father"s genes. However, a new study from Huntsman Cancer Institute (HCI) at the University of Utah reveals that the father"s sperm delivers much more complex genetic material than previously thought. The findings could lead to a diagnostic test to help couples deal with infertility. Researchers discovered particular genes packaged in a special way within the sperm, and that may promote the development of the fetus. "Our findings show that the father plays an active role in packaging his genome to help ensure a healthy baby," says study co-leader Brad Cairns, Ph.D., investigator with HCI and the Howard Hughes Medical Institute, and professor of oncological sciences at the University of Utah. "However, they also raise the possibility that a man"s aging, health and lifestyle may alter this packaging and negatively affect fertility and embryo development." During fetal development, certain genes make decisions about organ and tissue development. The new research shows that in sperm, these genes are wrapped in special packaging materials called "modified histones." These modified histones appear to be key factors in ensuring genes are activated or repressed at the right level, place and time, which helps the fertilized egg develop properly. Chromosomes are long strands of DNA containing thousands of genes, and their packaging helps determine which genes turn on and off. Understanding how these genes are activated or repressed leads to a better understanding of how disorders like birth defects and cancer develop. "Genes have on-and-off switches, and understanding them allows us to target them, leading to possible treatments, cures or prevention strategies," says Cairns. "That"s the good news." The study is set for publication June 14 - a week before Father"s Day - in the online edition of the journal Nature. The research involved collaboration between Cairns" lab at HCI and the University of Utah"s in vitro fertilization (IVF) and andrology lab led by Doug Carrell - along with their joint graduate student, Sue Hammoud. An implication of this study is that factors such as genetic mutations, age or lifestyle may affect sperm chromosome packaging, leading to infertility. "We are hopeful that this work will soon lead to a clinical diagnostic test that will help couples with infertility problems make better informed decisions regarding their prospects for a healthy child. We will also be testing if aspects of a man"s lifestyle - such as age, diet or health - affect proper packaging and fertility," says Cairns. Other future work includes how decision-making genes are packaged in eggs, which remains a major mystery. Notes: Huntsman Cancer Institute (HCI) at the University of Utah marks its 10th anniversary in 2009. HCI was founded by Jon M. Huntsman to fulfill his dream of finding a cure for cancer through genetic research. In the last 10 years, HCI has grown to become one of America"s major cancer research centers. HCI is part of the University of Utah healthcare system and is ranked consistently by U.S. News & World Report as one of the top cancer hospitals in the country. For more information about HCI, please visit www.huntsmancancer.org. Kathy Wilets University of Utah Health Sciences


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