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Analysis Of Edoxaban Phase II Data Provides Insight Into Reduced Bleeding Events Seen In Once-Daily Dosing
A sub-analysis of a Phase IIb multinational study(1) with edoxaban(2) - an investigational oral Factor Xa inhibitor - provides insights into why patients with non-valvular atrial fibrillation (AF) receiving edoxaban once daily (QD) experienced fewer bleeding events than patients given edoxaban twice a day (BID). The analysis finds that bleeding associated with edoxaban is most closely correlated with minimum concentration levels of the drug in the blood, and that these trough levels may best predict bleeding events, rather than total exposure or maximum concentration levels.
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NEJM Explores The Value-Based System Approach To Health Reform
In a New England Journal of Medicine perspective published online last night, Harvard Business School Professor Michael E. Porter outlines a national health care strategy. Recognizing "a new openness to changing a system that we all agree is broken," Porter emphasizes the need for a "value-based system" that both moves toward universal insurance coverage and restructures the care delivery system. Porter offers six steps critical to achieving such a system:
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Cooling Therapy For Cardiac Arrest Survivors Is As Cost-Effective As Accepted Treatments For Other Conditions
Cooling unconscious cardiac arrest survivors can increase survival and has a cost effectiveness comparable to other widely accepted treatments in modern health care, researchers report in Circulation: Cardiovascular Quality and Outcomes.
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Diabetes UK Shortlisted For Third Sector Excellence Awards

The Diabetes UK Media Relations Team has been shortlisted as one of five finalists for The Third Sector Excellence Awards in the category of Communications Team. The other finalists competing for one of the industry"s most prestigious awards are the Children"s Society, Crimestoppers Trust, EveryChild and Macmillan Cancer Support. Winners of all the awards will be announced at an awards ceremony on 24 September at the Grosvenor House Hotel in London. Paul McDonald, Head of Media at Diabetes UK, said: "It"s fantastic to have made it through to the final stages of such a prestigious award. "Our job is to raise awareness of diabetes and the profile of the organisation through the media. To be recognised amongst our peers is testament to the hard work, dedication and creativity in the team." Diabetes UK


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