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Gene Variations Can Be Barometer Of Behavior, Choices
Researchers at Brown University and the University of Arizona have determined that variations of three different genes in the brain (called single-nucleotide polymorphisms) may help predict a person"s tendency to make certain choices.
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Chronic Pelvic Pain Syndromes: Clinical, Urodynamic, And Urothelial Observations
UroToday.com - Patients with pain can present with various symptom complexes that include interstitial cystitis, vulvodynia, irritable bowel syndrome, myofascial pain or various causes of dyspareunia but when carefully evaluated, the majority have very similar findings. No matter what their primary complaint might be over 70% of patients will have hypertonic pelvic floor dysfunction and/or pain as well as a component of at least one visceral pain syndrome such as interstitial cystitis (the most common), chronic pelvic pain or irritable bowel syndrome.
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Empowering The Female Athlete: UPMC Sports Medicine Seeking Girls Ages 12 To 18 To Attend 'Total Package' Performance Training Conference
To bring together serious female athletes and teach them the latest injury-prevention techniques and enhance their mental training, nutrition, leadership and team-building skills, UPMC Sports Medicine is hosting Empowering the Female Athlete: ACL Injury Prevention and Beyond, June 14 to 19 at the Petersen Events Center, 3719 Terrace St., Oakland. Female athletes between ages 12 and 18 are invited to attend the conference, led by a range of UPMC experts who care for all types of patients, including scholastic and professional athletes.
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Continued Vigilance Against Drug-resistant Malaria Is Needed

Current combination malaria therapies recommended by the World Health Organisation (WHO) provide adequate treatment for mild malaria, according to a Cochrane Systematic Review of the evidence. However, selected trials had high failure rates for some combinations and evidence for the effectiveness of anti-malarial therapies is lacking in some vulnerable groups. Malaria kills more than a million people each year and accounts for more than a third of public health expenditure in some badly affected countries. Uncomplicated malaria is a mild version of the disease, but it can become serious and life threatening if left untreated. Resistance to the older antimalarials has led the WHO to recommend treatments combining an artemisinin-based drug with another longer-lasting drug to combat resistance. The review included 50 trials of artemisinin-based combination therapies (ACTs). Overall, the four combinations studied were effective for treatment of the most common type of malarial parasite. The researchers conclude that the recently introduced dihydroartemisinin-piperaquine performed well compared to the ACTs in current use and offers another potential first-line therapy for the disease. There were examples of treatment failure rates above 10% for all evaluated combinations. This is above the maximum allowable failure rate for a first line antimalarial as recommended by the WHO. "Patterns of resistance change from place to place and over time, so these results have to be interpreted with some caution," says lead researcher David Sinclair of the Liverpool School of Tropical Medicine in Liverpool, UK. "Our findings emphasise the need for continued vigilance in the monitoring of malaria and the development of resistance to antimalarial drugs." In addition, there were few studies focusing on the most at-risk groups, which are pregnant women and young infants. "The lack of evidence supporting the use of these drugs in pregnant women and infants represents a critical gap in our knowledge that must be addressed," says Sinclair. Jennifer Beal Wiley-Blackwell


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