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Skin-like Tissue Developed From Human Embryonic Stem Cells
Dental and tissue engineering researchers at Tufts University School of Dental Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts have harnessed the pluripotency of human embryonic stem cells (hESC) to generate complex, multilayer tissues that mimic human skin and the oral mucosa (the moist tissue that lines the inside of the mouth). The proof-of-concept study is published online in advance of print in Tissue Engineering Part A.
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Informa Announces A New Award For Best Review Paper
The editors of Disability & Rehabilitation and its sister publication, Disability & Rehabilitation: Assistive Technology have announced an annual award which will be given for the best review paper published in either of the two journals. Commencing in 2009, the Informa Best Review Paper Award will recognise valuable, high-impact research in the fields of disability, rehabilitation and assistive technology.
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CBP501 Enters Phase II Trials For The Treatment Of Non-Small Cell Lung Cancer
CanBas Co., Ltd. (Numazu, Shizuoka, "CanBas") and Takeda Pharmaceutical Company Limited (Osaka, "Takeda") together with Takeda"s wholly-owned subsidiary Millennium: The Takeda Oncology Company (Cambridge, MA, "Millennium") announced the advancement of CBP501 into Phase II clinical trials for the treatment of patients with non-small cell lung cancer (NSCLC). Current pre-clinical data suggest that CBP501 has the potential to induce cancer cell death through a mechanism of action that blocks the ability of cancer cells to transition through the cell cycle. Data from a previous Phase I study indicate that CBP501 may enhance anti-cancer cytotoxic activity when combined with selected chemotherapeutic drugs.
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Childhood Physical Abuse Linked To Cancer

Childhood physical abuse is associated with elevated rates of cancer in adulthood, according to a new study by University of Toronto researchers. The study, to be published July 15 in the journal Cancer, shows those individuals physically abused in childhood are more likely to develop cancer than those who have not been abused. Childhood physical abuse is associated with 49 per cent higher odds of cancer in adulthood, says Esme Fuller-Thomson of U of T"s Factor-Inwentash Faculty of Social Work and Department of Family and Community Medicine. "Few talk about childhood physical abuse and cancer in the same breath," says Fuller-Thomson. "From a public health perspective, it"s extremely important that clinicians be aware of the full range of risk factors for cancer. This research provides important new knowledge about a potential childhood abuse-cancer relationship." The study"s findings showed the association between childhood abuse and cancer remained significant even after controlling for three major potentially confounding factors: childhood stressors, adult health behaviors (i.e. smoking, physical inactivity, alcohol consumption) and adult socioeconomic status. Co-author Sarah Brennenstuhl, a doctoral student at Uof T, notes that various psychophysiological factors could help to explain the link between childhood physical abuse and cancer. "One important avenue for future research is to investigate dysfunctions in cortisol production - the hormone that prepares us for "fight or flight" -as a possible mediator in the abuse-cancer relationship." Joyann Callender University of Toronto


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