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1994 Group Responds To Innovation, Universities, Science and Skills Committee 'Students And Universities' Report
Responding to the Innovation, Universities, Science and Skills Committee (IUSS) report on "Students and Universities" Professor Paul Wellings, Chair of the 1994 Group of leading research intensive universities and Vice-Chancellor of Lancaster University said:
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Wanted: Healthy Food For Indigenous Communities
Food supplementation programs for women, infants and children are among the strategies that should be trialled to improve nutrition in Indigenous communities, according to an editorial published in the May 18 Indigenous Health issue of the Medical Journal of Australia.
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Financial Crisis Caused By Banking Chiefs Plagued With Hubris Syndrome
The current financial meltdown has in part been caused by bankers who display the attributes of Hubris Syndrome, a former leader of the Social Democratic Party (SDP) has claimed.
Mental Health

Blood Flow In Alzheimer's Disease

Dr. Jennifer C Palmer and colleagues at the University of Bristol have discovered that endothelin converting enzyme-2 (ECE-2) may cause the decrease in cerebral blood flow seen in Alzheimer"s disease. These results are presented in the July 2009 issue of the American Journal of Pathology. Alzheimer"s disease is the most common form of dementia. Aí² peptide, which accumulates in the brain of Alzheimer"s disease patients, is thought to lead to tightening of the blood vessels and reduction of cerebral blood flood. ECE-2 may contribute to these symptoms by converting an inactive precursor to endothelin-1, which constricts blood vessels. To determine if ECE-2 affects cerebral blood flow in Alzheimer"s disease, Palmer et al examined the expression of ECE-2. They found that ECE-2 levels were elevated in patients with Alzheimer"s disease and that Aí² could increase ECE-2 expression in vitro. These data indicate that ECE-2 levels are increased in response to Aí² and may cause the decrease in cerebral blood flow seen in Alzheimer"s disease. Palmer et al "suggest that [endothelin-1] receptor antagonists, already licensed for treating other diseases, could be of benefit in [Alzheimer"s disease] therapies." Palmer JC, Baig S, Kehoe PG, Love S: Endothelin-Converting Enzyme-2 is Increased in Alzheimer"s Disease. Am J Pathol 2009, 174: 2672-2680 Angela Colmone American Journal of Pathology


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